--- title: How to Submit to ClinVar from VarSome & VarSome Clinical description: From VarSome and VarSome Clinical, you can submit evidence to ClinVar. Learn how, here. image: https://blog.varsome.com/hubfs/ClinVarQ%26A.png --- [Skip to content](https://blog.varsome.com/annotated/submit-to-clinvar#main-content) ![VarSome logo white txts](https://blog.varsome.com/hs-fs/hubfs/VarSome%20logo%20white%20txts.png?width=160&height=40&name=VarSome%20logo%20white%20txts.png)Homepage - Editions - [VarSome.com](https://landing.varsome.com/varsome) - [VarSome Clinical](https://landing.varsome.com/varsome-clinical) - [VarSome Premium](https://landing.varsome.com/varsome-premium) - [VarSome API](https://landing.varsome.com/varsome-api) - [VarSome Insights](https://landing.varsome.com/varsome-insights) - About - [The Company](https://saphetor.com/) - [Contact Us](https://landing.varsome.com/contact) - [Distributors](https://landing.varsome.com/distributors) - [Become a Partner](https://landing.varsome.com/become-varsome-partner) - [Community](https://varsome.com/community-contributions/) - [Cite VarSome!](https://landing.varsome.com/citations) - Resources - [Datasources](https://varsome.com/datasources/) - [Germline Classification](https://varsome.com/about/resources/germline-implementation/) - [Somatic Classification](https://varsome.com/about/resources/somatic-implementation/) - [CNV Classification](https://varsome.com/about/resources/sv-implementation/) - [Help Center](https://docs.varsome.com/) - [Library](https://landing.varsome.com/whitepapers) - [IVDR](https://landing.varsome.com/ivdr-whitepaper) - [Legal & Compliance](https://docs.varsome.com/en/legal-compliance) - Blog - [Platform Updates](https://updates.varsome.com/en) - [Company News](https://news.varsome.com/en) - [VarSome Annotated](https://blog.varsome.com/annotated) - Editions - [VarSome.com](https://landing.varsome.com/varsome) - [VarSome Clinical](https://landing.varsome.com/varsome-clinical) - [VarSome Premium](https://landing.varsome.com/varsome-premium) - [VarSome API](https://landing.varsome.com/varsome-api) - [VarSome Insights](https://landing.varsome.com/varsome-insights) - About - [The Company](https://saphetor.com/) - [Contact Us](https://landing.varsome.com/contact) - [Distributors](https://landing.varsome.com/distributors) - [Become a Partner](https://landing.varsome.com/become-varsome-partner) - [Community](https://varsome.com/community-contributions/) - [Cite VarSome!](https://landing.varsome.com/citations) - Resources - [Datasources](https://varsome.com/datasources/) - [Germline Classification](https://varsome.com/about/resources/germline-implementation/) - [Somatic Classification](https://varsome.com/about/resources/somatic-implementation/) - [CNV Classification](https://varsome.com/about/resources/sv-implementation/) - [Help Center](https://docs.varsome.com/) - [Library](https://landing.varsome.com/whitepapers) - [IVDR](https://landing.varsome.com/ivdr-whitepaper) - [Legal & Compliance](https://docs.varsome.com/en/legal-compliance) - Blog - [Platform Updates](https://updates.varsome.com/en) - [Company News](https://news.varsome.com/en) - [VarSome Annotated](https://blog.varsome.com/annotated) ![](https://blog.varsome.com/hs-fs/hubfs/ClinVarQ%26A.png?width=1000&height=523&name=ClinVarQ%26A.png) Community Q&A # How to Submit to ClinVar from VarSome & VarSome Clinical ![Jason Armstrong](https://blog.varsome.com/hs-fs/hubfs/Jason%20HHS.jpeg?width=48&height=48&name=Jason%20HHS.jpeg) Jason Armstrong May 9, 2025 If you’re using VarSome or VarSome Clinical, you may have noticed the “Submit to ClinVar” button. However, if you are unsure what steps are required before a submission can be completed, this article will help you get started. For a more detailed explanation, please visit our [Help Center](https://docs.varsome.com/en/how-can-i-submit-to-clinvar). *Please note that this feature is not yet supported for CNVs.* # Submitting to ClinVar from VarSome ## Step 1: Register and Get API Access - Register your details at the [ClinVar Submission Portal.](https://submit.ncbi.nlm.nih.gov/clinvar/) - Request a Service Account and API key from ClinVar by emailing [clinvar@ncbi.nlm.nih.gov](mailto:clinvar@ncbi.nlm.nih.gov). *Note: These steps are mandatory to enable submission via VarSome and VarSome Clinical.*  ## Step 2: Select the Variant - Log in to VarSome. - Find your variant of interest. - Click ‘*Submit to ClinVar*’ in the ClinVar Card on the variant page. ![](https://blog.varsome.com/hs-fs/hubfs/image-png-May-09-2025-08-28-40-0510-AM.png?width=813&height=382&name=image-png-May-09-2025-08-28-40-0510-AM.png) *Note: If your API Key has not yet been configured, you will be prompted to set it up.* ## *Step 3: Complete Submission Form* You will be asked to fill in several fields: 1\. Assertion Criteria - Describe how you classified the variant and the supporting evidence. - Evidence may be a citation, URL, or file name. 2\. Clinical Significance - Add citation(s) - Database identifier (e.g., PubMed ID) or URL, not both. - Select a clinical significance label - Optional: add explanation, assertion score, and last evaluation date (yyyy-mm-dd format). - If ‘*Drug Response’* or ‘*Other*’ is selected, please add relevant explanations. *Note: If you provide a PubMed ID as a citation, the system will validate the citation and display the abstract.*  3\. Drug Response (if applicable) - Provide the condition name or ID related to the drug response. 4\. Condition(s) Set - Specify the condition name or ID. - Optional: Include local ID or local key. 5\. Observed In - Indicate whether affected individuals were observed. - Provide allele origin and, optionally, clinical features. 6\. Clinical Features (optional) - Add features by name or database ID. - Describe how the features were collected. - You can add a free-text comment with further clinical or diagnostic context. 7\. Submission Metadata Define: - Submission name (or use default submission ID). - Record status (new/update). - Release status (public/hold). 8\. Variant Set - Describe the variant using HGVS or chromosomal coordinates (not both). Once you have completed the form, click *Submit*. You can then track the submission status in your VarSome profile.  ![](https://blog.varsome.com/hs-fs/hubfs/image-png-May-09-2025-08-29-54-9786-AM.png?width=764&height=710&name=image-png-May-09-2025-08-29-54-9786-AM.png) ![](https://lh7-rt.googleusercontent.com/docsz/AD_4nXeSpaA3W6xJ3SMfTpxHjyQnz4jAq211ORMe0eYzSEg-gpzVsu7D1BgHc-N6ngS2z5OIvHKNX4I03VRGuATK5c_WZ2m9XvlWxEuC7jwt6HQdhQKOGATtWKe_LXnfBvEijq8Od6P3vQ?key=RHb0NqHxdLodat3zjTXelw) Status options include:  - Submitted - Processing - Error - Processed (not published) - Published # Submitting from VarSome Clinical ## *Step 1: Select Analysis* From the Dashboard or Analysis page, select the analysis of interest.  ## *Step 2: Choose Variant* In the results table, click the *‘Germline Classification’* card on the *Results Analysis* page. In this card, you’ll see the *‘Submit to ClinVar’* button, allowing you to complete your submission in the same way described above.  ![](https://lh7-rt.googleusercontent.com/docsz/AD_4nXdXFfQ1JsHSXb1cZcfOft9huvoUMvG_gJQ_8HLDJXma6F2VUBdfnzQVOrQ_jm2UIqAYCDiErxfkQHM7m4Sovuki87PcZjt2yW4LHxVinBmlF3SJBowJU5Cf3kubwsUvGzAY-_Vq4Q?key=RHb0NqHxdLodat3zjTXelw) ## *Step 3: Submit* Once submitted, you can track the status of your submission as described above.  ![](https://lh7-rt.googleusercontent.com/docsz/AD_4nXdGoHx8-lx7lfsvLPz1iQSkUjxf5v9OROlBuRg0C28JvexAODVhehhyb1tjNvX--E3deZmNEhIaGoUX4URuL6r9OEZ_BWDd1W0NMe6nJATRvsNPrgj39CheCpGkybPjo7TzE_hF?key=RHb0NqHxdLodat3zjTXelw) ![](https://lh7-rt.googleusercontent.com/docsz/AD_4nXcyMsEdY43JAZ_ksrbORWfNWENn2w88BB9q2HXS3aBGu8PNR_4b45S05IyV2Up01foiVtMpNebnxSc3worq_DgdVRqVlJxVKb3h---rhOktLqC2DgpGgWJqwuig3DtM18zMcAYDlA?key=RHb0NqHxdLodat3zjTXelw) # Additional Support For more support with VarSome or VarSome Clinical, contact our support team: [support@varsome.com](mailto:support@varsome.com).  For help with ClinVar API/accounts, please contact: [clinvar@ncbi.nlm.nih.gov](mailto:clinvar@ncbi.nlm.nih.gov). ## Share this post [mailto:https%3A%2F%2Fblog.varsome.com%2Fannotated%2Fsubmit-to-clinvar](mailto:https%3A%2F%2Fblog.varsome.com%2Fannotated%2Fsubmit-to-clinvar) ## Keep reading ### [![](https://blog.varsome.com/hs-fs/hubfs/Monogenic%20Diabetes.png?width=1000&height=523&name=Monogenic%20Diabetes.png) VarSome Annotated Minor Spliceosome Defects Drive Monogenic Autoimmune Diabetes](https://blog.varsome.com/annotated/minor-spliceosome-defects-drive-monogenic-autoimmune-diabetes) ### [![](https://blog.varsome.com/hs-fs/hubfs/Sickle%20Cell.png?width=1000&height=523&name=Sickle%20Cell.png) VarSome Annotated Promoter Editing and Fetal Hemoglobin Reactivation in Sickle Cell Disease](https://blog.varsome.com/annotated/promoter-editing-and-fetal-hemoglobin-reactivation-in-sickle-cell-disease) --- Privacy Policy · Legal · © 2025. 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